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SOX-10, EP268, IgG - 0.5ml
SOX-10 is a member of the sex-determining region Y-related HMG-box family and is a transcription factor that is expressed in pre-migratory and migrating neural crest cells. Following migration, it remains expressed in cells destined for glial, schwannian and melanocytic differentiation. SOX-10 is widely expressed in normal human tissues...
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Product information
Specification & product details.
SOX-10 is a member of the sex-determining region Y-related HMG-box family and is a transcription factor that is expressed in pre-migratory and migrating neural crest cells.
Following migration, it remains expressed in cells destined for glial, schwannian and melanocytic differentiation.
SOX-10 is widely expressed in normal human tissues including melanocytes and breast tissue and is an important marker in malignant tumours such as melanoma and breast carcinomas of basal-like and triple negative type, gliomas, and benign tumours such as schwannomas.
More importantly, SOX-10 has shown to be expressed in 97-100% of desmoplastic and spindle cell melanomas and has also shown to be expressed in 100% of nevi. Spindle cell and desmoplastic melanomas are rare variants of invasive cutaneous melanoma, with an annual incidence rate of approximately 2/100,000.
The majority of oligodendrogliomas and a large percentage of astrocytomas and poorly differentiated glioblastomas have been shown to express SOX-10.
Key Benefits:
• Clone: EP268
• Isotype: Rabbit IgG
• Immunogen: Recombinant fragment corresponding to residues in human SOX-10 protein
• Species: Rabbit
• Cellular Localisation: Nuclear
• Positive Control Tissue: Melanoma
• Pre-treatment: EDTA Buffer pH 8.0
• Incubation & Temperature: 30 min @ RT
• Intended Use: IVD
• Detection System: PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System
• Description/Type: Conc Rabbit Monoclonal Antibody
• Format: Purified immunoglobulin
• Sources: Mouse Monoclonal Antibody
Following migration, it remains expressed in cells destined for glial, schwannian and melanocytic differentiation.
SOX-10 is widely expressed in normal human tissues including melanocytes and breast tissue and is an important marker in malignant tumours such as melanoma and breast carcinomas of basal-like and triple negative type, gliomas, and benign tumours such as schwannomas.
More importantly, SOX-10 has shown to be expressed in 97-100% of desmoplastic and spindle cell melanomas and has also shown to be expressed in 100% of nevi. Spindle cell and desmoplastic melanomas are rare variants of invasive cutaneous melanoma, with an annual incidence rate of approximately 2/100,000.
The majority of oligodendrogliomas and a large percentage of astrocytomas and poorly differentiated glioblastomas have been shown to express SOX-10.
Key Benefits:
• Clone: EP268
• Isotype: Rabbit IgG
• Immunogen: Recombinant fragment corresponding to residues in human SOX-10 protein
• Species: Rabbit
• Cellular Localisation: Nuclear
• Positive Control Tissue: Melanoma
• Pre-treatment: EDTA Buffer pH 8.0
• Incubation & Temperature: 30 min @ RT
• Intended Use: IVD
• Detection System: PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System
• Description/Type: Conc Rabbit Monoclonal Antibody
• Format: Purified immunoglobulin
• Sources: Mouse Monoclonal Antibody
Pack size: 1
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